Product Identification 对氨基苯乙酮
【Product Name】4-Aminoacetophenone
【Synonyms】p-Acetylaniline
【CAS】99-92-3
【Formula】C8H9NO
【Molecular Weight】135.16999999999999
【EINECS】202-801-2
【RTECS】AM5500000
【RTECS Class】Agricultural Chemical and Pesticide
【Merck】13,412
【Beilstein/Gmelin】471493
【Beilstein Reference】4-14-00-00100
【EC Class】harmful
Physical and Chemical Properties
【Appearance】Light yellow to brown powder with a pleasant, characteristic odor.
【Solubility in water】Soluble
【Melting Point】101 - 103
【Boiling Point】293
【Vapor Pressure】0.0016 (25 C)
【Density】1.13 g/cm3 (20 C)
【pKa/pKb】11.83 (pKb)
【Partition Coefficient】.83
【Heat Of Vaporization】53.5 kJ/mol
【Usage】Chemical intermediate for flavaniline (basic dye), acetohexamide, and an oral hypoglycemic drug.
First Aid Measures
【Ingestion】If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage
【Storage】Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Do not ingest or inhale. Use with adequate ventilation. Wash clothing before reuse.
Hazards Identification
【Inhalation】
Causes respiratory tract irritation.
【Skin】Causes skin irritation.
【Eyes】Causes eye irritation.
【Ingestion】Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Overexposure may cause methemoglobinemia.
【EC Risk Phrase】R 22
【EC Safety Phrase】S 28 36/37
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety ggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis.
【Poison Class】4
Fire Fighting Measures
【Flash Point】132
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability and Reactivity
【Disposal Code】3
【Incompatibilities】Acids, acid chlorides, acid anhydrides, strong oxidizing agents, strong reducing agents.
【Stability】
Stable under normal temperatures and pressures.
【Decomposition】Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Transport Information
【HS Code】2922 39 00